AnalyzeDirect Governo RJM, Morris PG, Marsden CA, Chapman V. Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetized rat: an fMRI study. Br J Pharmacol. April 2008;153(7):1558-1567.
Full Text – Open Access
Publication Date
April 2008
How Analyze was Used
“All volume data acquired from each study were motion corrected to a middle volume, to correct for motion artefacts, prior to being masked (Analyze software, version 1.0 …), the process to remove all non-nervous tissue.”
Keywords
Administration, Oral
Amines/pharmacology
Analgesics/pharmacology
Animals
Blood Pressure/drug effects
Brain/metabolism
Brain Mapping/methods
Cyclohexanecarboxylic Acids/pharmacology
Disease Models, Animal
Infusions, Intravenous
Magnetic Resonance Imaging (MRI)/methods
Oxygen/blood
Pain/drug therapy
Pain Measurement/methods
Rats
Rats, Sprague-Dawley
gamma-Aminobutyric Acid/pharmacology
Author Affiliation(s)
School of Biomedical Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK. (RJMG, CAM, VC)
School of Physics and Astronomy, Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, UK. (RJMG, PGM)
ID# 1552
Tags: Amines/pharmacology, Analgesics/pharmacology, Animal Disease Models, Animals, Blood Pressure/drug effects, Brain Mapping/methods, Brain/metabolism, Cyclohexanecarboxylic Acids/pharmacology, gamma-Aminobutyric Acid/pharmacology, Intravenous Infusions, Magnetic Resonance Imaging (MRI)/methods, Oral Administration, Oxygen/blood, Pain Measurement/methods, Pain/drug therapy, Rats, Sprague-Dawley Rats