AnalyzeDirect Bhattacharya A, Seshadri M, Oven SD, Tόth K, Vaughan MM, Rustum YM. Tumor vascular maturation and improved drug delivery induced by methylselenocysteine leads to therapeutic synergy with anticancer drugs. Clin Cancer Res. June 2008;14(12):3926-3932.
Full Text – Open Access
Publication Date
June 2008
How Analyze was Used
“For determination of vessel lumen area, photomicrographs of CD31-stained sections (×400) were digitized at 1,350 dpi and areas were manually segmented using the region-of-interest module of the medical imaging software, Analyze (AnalyzeDirect).”
Keywords
Animals
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Capillary Permeability/drug effects
Carcinoma, Squamous Cell/blood supply/drug therapy/pathology
Cysteine/administration & dosage/analogs & derivatives
Drug Delivery Systems
Drug Synergism
Female
Head and Neck Neoplasms/blood supply/*drug therapy/pathology
Humans
Mice
Mice, Nude
Neovascularization, Pathologic/drug therapy/pathology
Organoselenium Compounds/administration & dosage
Selenocysteine/analogs & derivatives
Xenograft Model Antitumor Assays
Author Affiliation(s)
Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY, US. (AB, MS, SDO, KT, YMR)
Department of Preclinical Imaging Resource, Roswell Park Cancer Institute, Buffalo, NY, US. (MS)
Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY, US. (MMV)
ID# 1512
Tags: Animals, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Capillary Permeability/drug effects, Cysteine/administration & dosage/analogs & derivatives, Drug Delivery Systems, Drug Synergism, Female, Head and Neck Neoplasms/blood supply/drug therapy/pathology, Humans, Mice, Nude Mice, Organoselenium Compounds/administration & dosage, Pathologic Neovascularization/drug therapy/pathology, Selenocysteine/analogs & derivatives, Squamous Cell Carcinoma/blood supply/drug therapy/pathology, Xenograft Model Antitumor Assays