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Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET study

Egerton A, Shotbolt JP, Stokes PRA, Hirani E, Ahmad R, Lappin JM, Reeves SJ, Mehta MA, Howes OD, Grasby PM. Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET study. Neuroimage. March 2010;50(1):260-266.

Full Text – Open Access

Publication Date
March 2010

How Analyze was Used
“Image volumes were then transferred into ANALYZE (www.analyzedirect.com) (Robb and Hanson, 1991). Using a volume of interest (VOI) template (Hume et al., 2001) data were sampled from the dorsal striatum (2 × 140 voxels) and cerebellum (764 voxels).”

Keywords
Adult
Animals
Bupropion/administration & dosage/pharmacology
Cognition/physiology
Corpus Striatum/drug effects/metabolism/radionuclide imaging
Dopamine/metabolism
Dopamine Uptake Inhibitors/administration & dosage/pharmacology
Dose-Response Relationship, Drug
Extracellular Space/drug effects/metabolism/radionuclide imaging
Female
Humans
Male
Middle Aged
Neuropsychological Tests
Positron-Emission Tomography (PET)/methods
Raclopride
Rats
Rats, Sprague-Dawley

Author Affiliation(s)
Psychiatric Imaging, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. (AE, JPS, PRAS, JLM, SJR, MAM, ODH, PMG)

Division of Neurosciences and Mental Health, Imperial College London, UK. (AE, JPS, PRAS, JML, SJR, MAM, ODH, PMG)

Institute of Psychiatry, King’s College London, London SE5 8AF, UK. (AE, JML, SJR, MAM, ODH)

GlaxoSmithKline Clinical Imaging Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. (JPS)

MDX Research, GE Healthcare, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. (EH, RA)

ID# 1043

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