AnalyzeDirect Sen A, Capitano ML, Spernyak JA, Schueckler JT, Thomas S, Singh AK, Evans SS, Hylander BL, Repasky EA. Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models. Cancer Res. June 2011;71(11):3872-3880.
Full Text – Open Access
Publication Date
June 2011
How Analyze was Used
“Regions of interest (ROIs) for tumor and back muscle were drawn using commercially available software (Analyze 7.0; AnalyzeDirect).”
Keywords
Animals
Body Temperature/physiology
Cell Hypoxia/physiology
Colonic Neoplasms/blood supply/radiotherapy/therapy
Combined Modality Therapy
Disease Models, Animal
Extracellular Fluid/physiology
Female
Humans
Hyperthermia, Induced/methods
Mammary Neoplasms, Experimental/blood supply/radiotherapy/therapy
Melanoma, Experimental/blood supply/radiotherapy/therapy
Mice
Mice, Inbred BALB C
Author Affiliation(s)
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, US. (AS, MLC, JTS, ST, SSE, BLH, EAR)
Department of Animal Resources, Roswell Park Cancer Institute, Buffalo, NY, US. (JAS)
Department of Radiation Oncology, Roswell Park Cancer Institute, Buffalo, NY, US. (AKS)
ID# 669
Tags: Animal Disease Models, Animals, Body Temperature/physiology, Cell Hypoxia/physiology, Colonic Neoplasms/blood supply/radiotherapy/therapy, Combined Modality Therapy, Experimental Mammary Neoplasms/blood supply/radiotherapy/therapy, ExperimentalMelanoma/blood supply/radiotherapy/therapy, Extracellular Fluid/physiology, Female, Humans, Inbred BALB C Mice, Induced Hyperthermia/methods, Mice