AnalyzeDirect Challapalli A, Kenny LM, Hallett WA, Kozlowski K, Tomasi G, Gudi M, Al-Nahhas A, Coombes RC, Aboagye EO. 18F-ICMT-11, a caspase-3-specific PET tracer for apoptosis: biodistribution and radiation dosimetry. J Nucl Med. September 2013;54(9):1551-1556.
Full Text – Open Access
Publication Date
September 2013
How Analyze was Used
“To avoid tissue inhomogeneity, particularly near organ boundaries, the VOIs were defined within the boundaries of the normal-tissue organs, as visualized on the CT images and mapped to the corresponding emission scans using shape-based interpolation to extract the 18F activities with the ANALYZE analysis software (version 11).”
Keywords
18f-ICMT-11
Aged
Apoptosis/physiology
Azides/adverse effects/diagnostic use/pharmacokinetics
Biodistribution
Caspase 3/metabolism
Dosimetry
Female
Humans
Indoles/adverse effects/diagnostic use/pharmacokinetics
Male
Metabolic Clearance Rate
Middle Aged
Organ Specificity
Positron-Emission Tomography (PET)/methods
Radiation Dosage
Radiopharmaceuticals/adverse effects/diagnostic use/pharmacokinetics
Reproducibility of Results
Sensitivity and Specificity
Tissue Distribution
Author Affiliation(s)
Department of Surgery and Cancer, Imperial College London, London, UK. (AC, LAK, KK, GT, MG, RCC, EOA)
Imanova Centre for Imaging Studies, London, UK. (WAH)
Department of Radiology/Nuclear Medicine, Imperial College Healthcare NHS Trust, London, UK. (AAN)
ID# 308
Tags: 18f-ICMT-11, Aged, Apoptosis/physiology, Azides/adverse effects/diagnostic use/pharmacokinetics, Biodistribution, Caspase 3/metabolism, Dosimetry, Female, Humans, Indoles/adverse effects/diagnostic use/pharmacokinetics, Male, Metabolic Clearance Rate, Middle Aged, Organ Specificity, Positron-Emission Tomography (PET)/methods, Radiation Dosage, Radiopharmaceuticals/adverse effects/diagnostic use/pharmacokinetics, Reproducibility of Results, Sensitivity and Specificity, Tissue Distribution