AnalyzeDirect

Riss PJ, Hong YT, Williamson D, Caprioli D, Sitnikov S, Ferrari V, Sawiak SJ, Baron JC, Dalley JW, Fryer TD, Aigbirhio FI. Validation and quantification of [¹⁸F]altanserin binding in the rat brain using blood input and reference tissue modeling. J Cereb Blood Flow Metab. December 2011;31(12):2334-2342.

Full Text – Open Access

Publication Date
December 2011

How Analyze was Used
“The following regions of interest (ROIs) were manually defined on the MR atlas using Analyze 7.0 software (AnalyzeDirect, Overland Park, KS, USA): frontal cortex, whole cortex, striatum, hippocampus, and cerebellum.”

Keywords
Animals
Brain/metabolism/radionuclide imaging
Cerebellum/metabolism/radionuclide imaging
Cerebrovascular Circulation/physiology
Chromatography, High Pressure Liquid
Fluorine Radioisotopes/chemistry/diagnostic use
Ketanserin/analogs & derivatives/blood/chemical synthesis/pharmacokinetics
Models, Biological
Positron-Emission Tomography (PET)
Protein Binding
Quality Control
Radiopharmaceuticals/chemical synthesis/diagnostic use
Rats
Receptor, Serotonin, 5-HT2A/metabolism
Reference Standards

Author Affiliation(s)
Molecular Imaging Chemistry Laboratory, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. (PJR, VF, FIA)

Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. (PJR, YTH, DW, VF, SJS, TDF, FIA)

Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK. (PJR, DC, SJS, JCB, JWD, TDF, FIA)

Laboratory for Molecular Imaging, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. (YTH, DW, SS, SJS, TDF, FIA)

Department of Experimental Psychology, University of Cambridge, Cambridge, UK. (DC, JWD)

Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. (SS, JCB)

Centre de Psychiatrie et Neurosciences, INSERM U894, Université Paris, Paris, France. (JCB)

Department of Psychiatry, University of Cambridge, Cambridge, UK. (JWD)

ID# 705

Tags: 5-HT2A Serotonin Receptor/metabolism, Animals, Biological Models, Brain/metabolism/radionuclide imaging, Cerebellum/metabolism/radionuclide imaging, Cerebrovascular Circulation/physiology, Fluorine Radioisotopes/chemistry/diagnostic use, High Pressure Liquid Chromatography, Ketanserin/analogs & derivatives/blood/chemical synthesis/pharmacokinetics, Positron Emission Tomography (PET), Protein Binding, Quality Control, Radiopharmaceuticals/chemical synthesis/diagnostic use, Rats, Reference Standards