Nobuhisa Kanahara, et al. The effects of cumulative antipsychotic dose on brain structures in patients with schizophrenia: Observational study of multiple CT scans over a long-term clinical course Psychiatry Research: Neuroimaging.
November 26, 2021
How Analyze was Used
“Measurement of the region of interest in the present study was referenced to the analysis reported by Davis et al. (1998) measuring ventricle-level slices of CT images, which was similar to our study. With
the ANALYZE 12.0 [Analyze Direct, Mayo Clinic, USA] imaging software, the present study selected three specific slices from the brain CT imaging (usually 15~20 slices per a scan) based on the following algorithm (Fig. 1): First, for the first scan in a given patient, all slices (usually 5~6 slices) with bilateral lateral ventricles (LV) clearly visible from rostral to caudal direction are identified. Then, the most rostral slice among them is defined as the upper-level slice, and the most caudal slice is defined as the lower-level slice image. The slice halfway between the upper- and lower-level slices is defined as the mid-level slice. For the subsequent CT scan, the three slices which are the closest to the three slices defined in the first scan are identified with reference to the form ofthe cranial bone. For each of the three slices, voxels inside of the cranial bone (a), voxels within the brain ventricles (LV, 3rd and 4th ventricles) (b), and voxels within cerebrospinal fluid (CSF) areas outside the cerebral sulci and gyri (c) were calculated using the semiautomatic manual tracing function of ANALYZE 12.0. Finally, for each slice, the volume reduction rate (%) was calculated by (b + c)/a× 100. This indicator means the percentage of space of CSF within the cranial volume. The change of the volume from one CT scan to the next was divided by its corresponding interval (in years) to obtain the annual volume change used in the analysis. ”
Atypical antipsychotic, Dopamine supersensitivity psychosis, High-dose treatment, Polytherapy, Typical antipsychotic, Ventricle
Chiba University, Chiba, Japan