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Wu K, O’Keeffe D, Politis M, O’Keeffe GC, Robbins TW, Bose SK, Brooks DJ, Piccini P, Barker RA. The catechol-O-methyltransferase Val¹⁵⁸Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson’s disease: a PET study. Brain. August 2012;135(Pt 8):2449-2457.

Full Text – Open Access

Publication Date
August 2012

How Analyze was Used
“Each object map was applied to the dynamic images and the ¹⁸F-DOPA net influx constant (Ki) values for each individual region were computed using RPM in ANALYZE 8.1 software.”

Keywords
Aged
Catechol O-Methyltransferase/genetics
Corpus Striatum/radionuclide imaging
Dopamine/metabolism
Female
Frontal Lobe/radionuclide imaging
Genetic Variation
Genotype
Humans
Male
Methionine/genetics
Middle Aged
Parkinson Disease/genetics/radionuclide imaging
Polymorphism, Genetic/genetics
Positron-Emission Tomography (PET)/methods
Valine/genetics

Author Affiliation(s)
Centre for Neuroscience, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK. (KW, MP, SKB, DJB, PP)

Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. (DO, GCO, RAB)

Department of Experimental Psychology, University of Cambridge, Cambridge, UK. (TWR)

ID# 599

Tags: Aged, Catechol O-Methyltransferase/genetics, Corpus Striatum/radionuclide imaging, Dopamine/metabolism, Female, Frontal Lobe/radionuclide imaging, Genetic Polymorphism/geneticsGenetic Variation, Genotype, Humans, Male, Methionine/genetics, Middle Aged, Parkinson Disease/genetics/radionuclide imaging, Positron-Emission Tomography (PET)/methods, Valine/genetics