AnalyzeDirect Gil M, Seshadri M, Komorowski MP, Abrams SI, Kozbor D. Targeting CXCL12/CXCR4 signaling with oncolytic virotherapy disrupts tumor vasculature and inhibits breast cancer metastases. Proc Natl Acad Sci U S A. April 2013;110(14):E1291-1300.
Full Text – Open Access
Publication Date
April 2013
How Analyze was Used
“Metastatic deposits were manually traced using the medical imaging software, Analyze (AnalyzeDirect). Total number of nodules and extent of metastatic burden (number of voxels) were calculated from three animals per group in a blinded manner.”
Keywords
Analysis of Variance
Animals
Breast Neoplasms/pathology/therapy/virology
Chemokine CXCL12/metabolism
Enzyme-Linked Immunosorbent Assay
Female
Flow Cytometry
Immunohistochemistry
Lung Neoplasms/prevention & control/secondary
Mice
Mice, Inbred BALB C
Neovascularization, Pathologic/prevention & control/virology
Oligonucleotides/genetics
Oncolytic Virotherapy/methods
Peptides/pharmacology/therapeutic use
Receptors, CXCR4/antagonists & inhibitors/metabolism
Signal Transduction/physiology
Vaccinia virus
Author Affiliation(s)
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, US. (MG, MPK, SIA, DK)
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, US. (MS)
ID# 444
Tags: Analysis of Variance, Animals, Breast Neoplasms/pathology/therapy/virology, Chemokine CXCL12/metabolism, CXCR4 Receptors/antagonists & inhibitors/metabolism, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Immunohistochemistry, Inbred BALB C Mice, Lung Neoplasms/prevention & control/secondary, Mice, Oligonucleotides/genetics, Oncolytic Virotherapy/methods, Pathologic Neovascularization/prevention & control/virology, Peptides/pharmacology/therapeutic use, Signal Transduction/physiology, Vaccinia virus