Analyze Publications Database

Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension

Alfonso Eirin1, Behzad Ebrahimi1, Soon Hyo Kwon1, Justin A. Fiala1, Barbara J. Williams1, John R. Woollard1, Quan He2, Ramech C. Gupta3, Hani N. Sabbah3, Y.S. Prakash4, Stephen C. Textor1, Amir Lerman5, Lilach O. Lerman1,5. Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension. Journal of the American Heart Association. 31 May 2016.

Full Text – Open Access

Publication Date
May 2016

How Analyze was Used
“The entire LV was scanned throughout the cardiac cycle to obtain cardiac systolic function, end‐diastolic volume (EDV), and LV muscle mass (LVMM). Early (E) and late (A) LV filling rates were obtained from the volume/time curve, and myocardial perfusion from time‐attenuation curves obtained from the anterior cardiac wall, as described. Images were analyzed with the Analyze software package (Biomedical Imaging Resource; Mayo Clinic, Rochester, MN). […] An LV transmural portion (2 cm3) was scanned, and images analyzed, as described. The spatial density and average diameter of microvessels in the subepicardium and subendocardium were calculated using Analyze, and vessel tortuosity (maturity index) calculated.”

Keywords
bendavia
heart failure
hypertension
mitochondria
renal artery stenosis
renovascular hypertension

Author Affiliation(s)
1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN
2Diabetes and Obesity Research Center, Sanford‐Burnham Medical Research Institute, Orlando, FL
3Division of Cardiovascular Medicine, Henry Ford Health System, Detroit, MI
4Department of Anesthesiology, Mayo Clinic, Rochester, MN
5Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN

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