AnalyzeDirect Suidan GL, Dickerson JW, Johnson HL, Chan TW, Pavelko KD, Pirko I, Seroogy KB, Johnson AJ. Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability. J Neuroinflammation. September 2012;9:218.
Full Text – Open Access
Publication Date
September 2012
How Analyze was Used
“Analyze 10 software … was used to quantify the three-dimensional volume of gadolinium leakage from vasculature as well as the volume of microhemorrhage.”
Keywords
Animals
CD8-Positive T-Lymphocytes/physiology
Capillary Permeability/physiology
Cell Survival/drug effects/physiology
Central Nervous System/physiology
Mice
Mice, Inbred C57BL
Models, Animal
Neuropilin-1/antagonists & inhibitors/metabolism
Peptides/pharmacology
RNA, Messenger/metabolism
Vascular Endothelial Growth Factor A/metabolism
Vascular Endothelial Growth Factor Receptor-1/genetics/metabolism
Vascular Endothelial Growth Factor Receptor-2/genetics/metabolism
Author Affiliation(s)
Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH, 45267, US. (GLS, JWD, TWC, KBS, AJJ)
Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, US. (GLS, JWD, IP, KBS)
Department of Neuroscience, Mayo Clinic, Rochester, MN, 55905, US. (IP)
Department of Neurology, Mayo Clinic, Rochester, MN, 55905, US. (HLJ, AJJ)
Department of Immunology, Mayo Clinic, Gugenheim Building 4-11C, 200 First St. SW, Rochester, MN, 55905, US. (HLJ, KDP, AJJ)
ID# 986
Tags: Animal Models, Animals, Capillary Permeability/physiology, CD8-Positive T-Lymphocytes/physiology, Cell Survival/drug effects/physiology, Central Nervous System/physiology, Inbred C57BL Mice, Messenger RNA/metabolism, Mice, Neuropilin-1/antagonists & inhibitors/metabolism, Peptides/pharmacology, Vascular Endothelial Growth Factor A/metabolism, Vascular Endothelial Growth Factor Receptor-1/genetics/metabolism, Vascular Endothelial Growth Factor Receptor-2/genetics/metabolism