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Johnström P, Fryer TD, Richards HK, Maguire JJ, Clark JC, Pickard JD, Davenport AP. Positron emission tomography of [¹⁸F]-big endothelin-1 reveals renal excretion but tissue-specific conversion to [¹⁸F]-endothelin-1 in lung and liver. Br J Pharmacol. February 2010;159(4):812-819.

Full Text – Open Access

Publication Date
February 2010

How Analyze was Used
“Regions of interest were delineated for the organs of interest using Analyze (AnalyzeDirect Inc, Lenexa, KS, USA) to construct time-activity curves (Robb et al., 1989).”

Keywords
Animals
Aspartic Acid Endopeptidases/antagonists & inhibitors/metabolism
Autoradiography
Azepines/pharmacology
Endothelin-1/administration & dosage/metabolism/pharmacokinetics
Enzyme Activation
Fluorine Radioisotopes
Glycopeptides/pharmacology
Half-Life
Indoles/pharmacology
Infusions, Intravenous
Kidney/drug effects/metabolism/radionuclide imaging
Lung/drug effects/metabolism/radionuclide imaging
Male
Metalloendopeptidases/antagonists & inhibitors/metabolism
Molecular Imaging
Molecular Probe Techniques
Positron-Emission Tomography (PET)
Protease Inhibitors/pharmacology
Rats
Rats, Sprague-Dawley
Receptor, Endothelin A/antagonists & inhibitors/metabolism
Tissue Distribution
Whole Body Imaging

Author Affiliation(s)
Clinical 1 Clinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK. (PJ, JJM, APD)

Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK. (TDF, JCC, JDP)

Academic Neurosurgery Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK. (HKR, JDP)

ID# 1106

Tags: Animals, Aspartic Acid Endopeptidases/antagonists & inhibitors/metabolism, Autoradiography, Azepines/pharmacology, Endothelin A Receptor/antagonists & inhibitors/metabolism, Endothelin-1/administration & dosage/metabolism/pharmacokinetics, Enzyme Activation, Fluorine Radioisotopes, Glycopeptides/pharmacology, Half-Life, Indoles/pharmacology, Intravenous Infusions, Kidney/drug effects/metabolism/radionuclide imaging, Lung/drug effects/metabolism/radionuclide imaging, Male, Metalloendopeptidases/antagonists & inhibitors/metabolism, Molecular Imaging, Molecular Probe Techniques, Positron Emission Tomography (PET), Protease Inhibitors/pharmacology, Rats, Sprague-Dawley Rats, Tissue Distribution, Whole Body Imaging