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Johnson HL, Willenbring RC, Jin F, Manhart WA, LaFrance SJ, Pirko I, Johnson AJ. Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption. PLoS One. October 2014;9(10):e111401.

Full Text – Open Access

Publication Date
October 2014

How Analyze was Used
“Analyze 11.0 software … was used to quantify the 3D volume of CNS vascular permeability.”

Keywords
Astrocytes
Cell Disruption
Central Nervous System
Confocal Microscopy
Magnetic Resonance Imaging (MRI)
T Cells
Tight Junctions
Vascular Permeability

Author Affiliation(s)
Department of Neurology, Mayo Clinic, Rochester, Minnesota, US. (HLJ, IP, AJJ)

Department of Immunology, Mayo Clinic, Rochester, Minnesota, US. (HLJ, RCW, FJ, WAM, SJL, AJJ)

Neurobiology of Disease Graduate Program, Mayo Graduate School, Rochester, Minnesota, US. (HLJ)

Virology and Gene Therapy Graduate Program, Mayo Graduate School, Rochester, Minnesota, US. (RCW)

ID# 1184

Tags: Astrocytes, Cell Disruption, Central Nervous System, Confocal Microscopy, Magnetic Resonance Imaging (MRI), T Cells, Tight Junctions, Vascular Permeability