AnalyzeDirect Decker NK, Abdelmoneim SS, Yaqoob U, Hendrickson H, Hormes J, Bentley M, Pitot H, Urrutia R, Gores GJ, Shah VH. Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liver. Am J Pathol. October 2008;173(4):1002-1012.
Full Text – Open Access
Publication Date
October 2008
How Analyze was Used
“Liver tissue was encased in paraffin and scanned at 20-μm voxel resolution using a bench-top scanner [Jorgensen et al. 1998]. Reconstructed images were studied using Analyze 7.0 software.”
Keywords
Animals
Animals, Genetically Modified
Anoikis
Antigens, Polyomavirus Transforming/metabolism
Cathepsin B/metabolism
Cell Line, Tumor
Down-Regulation
Female
Humans
Liver Neoplasms/blood supply/enzymology/metabolism/pathology
Mice
Mice, SCID
Models, Biological
Neoplasm Metastasis
Nitric Oxide/metabolism
Nitric Oxide Synthase Type III/deficiency
Pancreatic Neoplasms/pathology
Rats
Stromal Cells/metabolism/pathology
Transduction, Genetic
Author Affiliation(s)
Department of Physiology,Gastroenterology Research Unit, Cancer Cell Biology Program, Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN, US. (NKD, SSA, UY, HH, JH, RU, GJG, VHS)
Department of Biological Sciences, Minnesota State University, Mankato, MN, US. (MB)
Cancer Center, University of Wisconsin, Madison, WI, US. (HP)
ID# 1472
Tags: Animals, Anoikis, Biological Models, Cathepsin B/metabolism, Down-Regulation, Female, Genetic Transduction, Genetically Modified Animals, Humans, Liver Neoplasms/blood supply/enzymology/metabolism/pathology, Mice, Neoplasm Metastasis, Nitric Oxide Synthase Type III/deficiency, Nitric Oxide/metabolism, Pancreatic Neoplasms/pathology, Polyomavirus Transforming Antigens/metabolism, Rats, SCID Mice, Stromal Cells/metabolism/pathology, Tumor Cell Line