Analyze Publications Database

Metabolic activities affect femur and lumbar vertebrae remodeling, and anti-resorptive risedronate disturbs femoral cortical bone remodeling

Mi Yeong Kim et al. Metabolic activities affect femur and lumbar vertebrae remodeling, and anti-resorptive risedronate disturbs femoral cortical bone remodeling Experimental & Molecular Medicine.

Publication Date
January 12, 2021

How Analyze was Used
“Trabecular and cortical bone microarchitectures (femoral and lumbar) were assessed by performing high‐resolution microcomputed tomography (µCT) analysis. The µCT images were obtained using a Quantum FX micro CT system (PerkinElmer, Caliper Life Sciences, Hopkinton, MA, USA). The X-ray source was set to a voltage of 90 kVp, a current of 180 μA, and a field-of-view of 10 mm. Each distal femur was scanned in the region proximal to the growth plate and the fourth lumbar vertebra (L4) was scanned in the center of the vertebral body. Three-dimensional structural analyses of trabecular and cortical bone sites were performed using Analyze software, version 12.0 (AnalyzeDirect, Overland Park, KS, USA). Trabecular bone morphometry parameters were calculated for the BMD, bone volume/total volume (BV/TV) ratio, trabecular number (Tb.N), trabecular thickness (Tb.Th), and trabecular separation (Tb.Sp). In addition, cortical bone parameters, including the BMD, cortical area, and cortical thickness, were measured.”

Keywords
Bone, Bone quality and biomechanics, Micro-CT, Metabolic activities, Lumbar vertebrae remodeling, Anti-resorptive bisphosphonate treatment, Femoral fractures, Osteoblasts, Bone microarchitecture analysis

Author Affiliation(s)
Yeungnam University College of Medicine, Daegu, Korea

Tags: , , , , , , , ,