AnalyzeDirect Brownell AL, Canales K, Chen YI, Jenkins BG, Owen C, Livni E, Yu M, Cicchetti F, Sanchez-Pernaute R, Isacson O. Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson’s disease model. Neuroimage. October 2003;20(2):1064-1075.
Publication Date
October 2003
How Analyze was Used
“A segmentation routine in ANALYZE was used to separate the brain from the surrounding tissue in the MRI data. PET data were then thresholded and coregistered to its respective MRI data using the NMI (Normalized Mutual Information) voxel match algorithm of the ANALYZE software package and cubic spline interpolation.”
Keywords
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Brain/pathology/physiopathology/radionuclide imaging
Brain Chemistry/physiology
Brain Mapping
Cerebrovascular Circulation/physiology
Dopamine Agents/toxicity
Dopamine Plasma Membrane Transport Proteins
Energy Metabolism/physiology
Glucose/metabolism
Macaca fascicularis
Magnetic Resonance Imaging (MRI)
Male
Membrane Glycoproteins
Membrane Transport Proteins/metabolism
Motor Activity/physiology
Nerve Tissue Proteins
Oxygen/blood
Oxygen Consumption/physiology
Parkinson Disease, Secondary/chemically induced/pathology/physiopathology
Receptors, Dopamine D2/drug effects/metabolism
Reproducibility of Results
Tomography, Emission-Computed
Author Affiliation(s)
Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, US. (ALB, KC, YIC, BGJ, EL, MY)
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, US. (CO)
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, US. (RSP, OI)
Udall Parkinson’s Disease Research Center of Excellence, Neuroregeneration Laboratory, McLean Hospital, Belmont, MA 02478, US. (ALB, FC, OI)
ID# 2466
Tags: 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine, Animals, Brain Chemistry/physiology, Brain Mapping, Brain/pathology/physiopathology/radionuclide imaging, Cerebrovascular Circulation/physiology, Dopamine Agents/toxicity, Dopamine D2 Receptors/drug effects/metabolism, Dopamine Plasma Membrane Transport Proteins, Emission-Computed Tomography, Energy Metabolism/physiology, Glucose/metabolism, Macaca fascicularis, Magnetic Resonance Imaging (MRI), Male, Membrane Glycoproteins, Membrane Transport Proteins/metabolism, Motor Activity/physiology, Nerve Tissue Proteins, Oxygen Consumption/physiology, Oxygen/blood, Reproducibility of Results, Secondary Parkinson Disease/chemically induced/pathology/physiopathology