AnalyzeDirect

Jessica J. Steventon^1,2,3,4, Rebecca C. Trueman^2,5, Da Ma^6,7, Emma Yhnell^2,3, Zubeyde Bayram-Weston^2,3, Marc Modat⁶, Jorge Cardoso⁶, Sebastian Ourselin⁶, Mark Lythgoe⁷, Andrew Stewart⁴, Anne E. Rosser^2,3,8 & Derek K. Jones^1,3. Longitudinal in vivo MRI in a Huntington’s disease mouse model: Global atrophy in the absence of white matter microstructural damage. Scientific Reports. September 1 2016.

Full Text – Open Access

Publication Date
September 2016

How Analyze was Used
“Cortical thickness was measured on approximately the same coronal sections for both the MRI images and the prepared brain sections. Analysis was conducted using Analyze software (version 10.0) for the MRI images and using a Leica microscope at a 5x objective with background correction for uneven illumination for the mounted brain sections.”

Keywords
Experimental models of disease, Neurological disorders, Neurological manifestations, Translational research

Author Affiliation(s)
¹ Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Park Place, Cardiff, CF10 3AT, UK
² Brain Repair Group, Life Science Building, 3rd Floor, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK
³ Neuroscience and Mental Health Research Institute, Cardiff University, Hadyn Ellis Building, Cathays, Cardiff, CF24 4HQ, UK
⁴ Experimental MRI Centre, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK
⁵ School of Life Sciences, Queen’s Medical Centre, Nottingham University, Nottingham, NG7 2UH, UK
⁶ Centre for Medical Imaging Computing, University College London, London, UK
⁷ Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK
⁸ Institute of Psychological Medicine and Neurology, School of Medicine, Hadyn Ellis Building, Maindy Road, Cathays, Cardiff CF24 4HQ, UK

Tags: Experimental models of disease, Huntington Disease, Neurological disorders, Neurological manifestations, Translational research