AnalyzeDirect Zhang H, Wang L, Park JB, Park P, Yang VC, Hollister SJ, La Marca F, Lin CY. Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury. Arthritis Res Ther. November 2009;11(6):R172.
Full Text – Open Access
Publication Date
November 2009
How Analyze was Used
“A procedure described previously was followed to quantitatively analyze the obtained image slices using Analyze 7.0 software (AnalyzeDirect, Overland Park, KS, USA) [Zhang et al. 2009].”
Keywords
Animals
Bone Morphogenetic Protein 2/biosynthesis/drug effects
Drug Carriers/administration & dosage
Gels
Gene Expression/drug effects
Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage
Intervertebral Disc/drug effects/injuries
Intervertebral Disc Degeneration/drug therapy
Lactic Acid/administration & dosage
Polyethylene Glycols/administration & dosage
Polyglycolic Acid/administration & dosage
RNA, Messenger/analysis
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Simvastatin/administration & dosage
Author Affiliation(s)
Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, US. (HZ, LW, PP, SJH, FLM, CYL)
Department of Biomedical Engineering, University of Michigan, 2200 Bonisteel Blvd., Ann Arbor, MI 48109-2099, US. (HZ, SJH, FLM, CYL)
Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, US. (JBP, VCY)
ID# 1210
Tags: Animals, Bone Morphogenetic Protein 2/biosynthesis/drug effects, Drug Carriers/administration & dosage, Gels, Gene Expression/drug effects, Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage, Intervertebral Disc Degeneration/drug therapy, Intervertebral Disc/drug effects/injuries, Lactic Acid/administration & dosage, Messenger RNA/analysis, Polyethylene Glycols/administration & dosage, Polyglycolic Acid/administration & dosage, Rats, Reverse Transcriptase Polymerase Chain Reaction, Simvastatin/administration & dosage, Sprague-Dawley Rats