AnalyzeDirect Wislez M, Spencer ML, Izzo JG, Juroske DM, Balhara K, Cody DD, Price RE, Hittelman WN, Wistuba, II, Kurie JM. Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras. Cancer Res. April 2005;65(8):3226-3235.
Full Text – Open Access
Publication Date
April 2005
How Analyze was Used
“Lesion volume was measured with ‘Analyze’ software (AnalyzeDirect, Inc., Lenexa, KS).”
Keywords
Adenocarcinoma/drug therapy/enzymology/genetics
Adenoma/drug therapy/enzymology/genetics/pathology
Animals
Cell Line, Tumor
Cell Transformation, Neoplastic/drug effects/metabolism
Disease Progression
Enzyme Activation
Genes, ras/genetics
Hyperplasia
Lung Neoplasms/drug therapy/enzymology/genetics
Macrophages, Alveolar/drug effects/enzymology/pathology
Mice
Mutation
Precancerous Conditions/drug therapy/enzymology/genetics/pathology
Protein Kinase Inhibitors/pharmacology
Protein Kinases/metabolism
Protein-Serine-Threonine Kinases/metabolism
Proto-Oncogene Proteins/metabolism
Proto-Oncogene Proteins c-akt
Pulmonary Alveoli/drug effects/enzymology/pathology
Ribosomal Protein S6 Kinases/biosynthesis
Sirolimus/analogs & derivatives/pharmacology
TOR Serine-Threonine Kinases
Author Affiliation(s)
Department of 1Thoracic/Head and Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, US. (MW, DMJ, KB, IIW, JMK)
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX, US. (MLS, IIW)
Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, TX, US. (JGI, WNH)
Department of Imaging Physics, University of Texas M.D. Anderson Cancer Center, Houston, TX, US. (DDC, REP)
ID# 2076
Tags: Adenocarcinoma/drug therapy/enzymology/genetics, Adenoma/drug therapy/enzymology/genetics/pathology, Alveolar Macrophages/drug effects/enzymology/pathology, Animals, Disease Progression, Enzyme Activation, Genes_ras/genetics, Hyperplasia, Lung Neoplasms/drug therapy/enzymology/genetics, Mice, Mutation, Neoplastic Cell Transformation/drug effects/metabolism, Precancerous Conditions/drug therapy/enzymology/genetics/pathology, Protein Kinase Inhibitors/pharmacology, Protein Kinases/metabolism, Protein-Serine-Threonine Kinases/metabolism, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins/metabolism, Pulmonary Alveoli/drug effects/enzymology/pathology, Ribosomal Protein S6 Kinases/biosynthesis, TOR Serine-Threonine Kinases, Tumor Cell Line