AnalyzeDirect Boothman L, Raley J, Denk F, Hirani E, Sharp T. In vivo evidence that 5-HT2C receptors inhibit 5-HT neuronal activity via a GABAergic mechanism. Br J Pharmacol. December 2006;149(7):861-869.
Full Text – Open Access
Publication Date
December 2006
How Analyze was Used
“Data were transferred into ANALYZE-AVW imaging software and a standard volume of interest (VOI) template was projected onto each volume. Eight VOIs were sampled, including frontal with cingulate cortex (452 voxels), striatum (404 voxels), hippocampus (264 voxels) and cerebellum (576 voxels).”
Keywords
Action Potentials/drug effects
Aminopyridines/pharmacology
Animals
Brain Chemistry/drug effects
Dopamine Agonists/metabolism/pharmacology
Dopamine Antagonists/pharmacology
Dose-Response Relationship, Drug
GABA Antagonists/pharmacology
Glutamate Decarboxylase/analysis
Immunohistochemistry
Indoles/pharmacology
Male
Neural Inhibition/drug effects
Neurons/chemistry/drug effects/metabolism
Picrotoxin/pharmacology
Piperazines/pharmacology
Positron-Emission Tomography (PET)
Proto-Oncogene Proteins c-fos/analysis
Pyrazines/metabolism/pharmacology
Pyridines/pharmacology
Quinoxalines/metabolism/pharmacology
Raphe Nuclei/chemistry/cytology/drug effects/metabolism
Rats
Rats, Sprague-Dawley
Receptor, Serotonin, 5-HT2C/analysis/drug effects/metabolism
Ritanserin/pharmacology
Serotonin/metabolism
gamma-Aminobutyric Acid/metabolism
Author Affiliation(s)
University Department of Pharmacology, Oxford, UK. (LB, JR, TS)
Hammersmith Imanet Ltd., Cyclotron Building, Hammersmith Hospital, London, UK. (EH)
ID# 2016
Tags: 5-HT2C Serotonin Receptor/analysis/drug effects/metabolism, Action Potentials/drug effects, Aminopyridines/pharmacology, Animals, Brain Chemistry/drug effects, Dopamine Agonists/metabolism/pharmacology, Dopamine Antagonists/pharmacology, Drug Dose-Response Relationship, GABA Antagonists/pharmacology, gamma-Aminobutyric Acid/metabolism, Glutamate Decarboxylase/analysis, Immunohistochemistry, Indoles/pharmacology, Male, Neural Inhibition/drug effects, Neurons/chemistry/drug effects/metabolism, Picrotoxin/pharmacology, Piperazines/pharmacology, Positron Emission Tomography (PET), Proto-Oncogene Proteins c-fos/analysis, Pyrazines/metabolism/pharmacology, Pyridines/pharmacology, Quinoxalines/metabolism/pharmacology, Raphe Nuclei/chemistry/cytology/drug effects/metabolism, Rats, Ritanserin/pharmacology, Serotonin/metabolism, Sprague-Dawley Rats