AnalyzeDirect Pillai RG, Forster M, Perumal M, Mitchell F, Leyton J, Aibgirhio FI, Golovko O, Jackman AL, Aboagye EO. Imaging pharmacodynamics of the alpha-folate receptor-targeted thymidylate synthase inhibitor BGC 945. Cancer Res. May 2008;68(10):3827-3834.
Full Text – Open Access
Publication Date
May 2008
How Analyze was Used
“[18F]FLT-PET studies were carried out on a dedicated small animal PET scanner, quad-HIDAC….The image data sets obtained were visualized using the Analyze software (version 6.0).”
Keywords
Animals
Carrier Proteins/metabolism
Chemistry, Pharmaceutical/methods
Female
Fluorodeoxyglucose F18/pharmacology
Folate Receptor 1
Folate Receptors, GPI-Anchored
Humans
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Positron-Emission Tomography (PET)/methods
Quinazolines/pharmacology
Receptors, Cell Surface/metabolism
Thymidylate Synthase/antagonists & inhibitors
Time Factors
Tumor Markers, Biological/metabolism
Author Affiliation(s)
Department of Molecular Therapy, Imperial College London, Faculty of Medicine, Hammersmith Hospital Campus, London, UK. (RGP, MP, JL, EOA)
Section of Medicine, The Institute of Cancer Research, Sutton, Surrey, UK. (MF, FM, ALJ)
Wolfson Brain Imaging Center, University of Cambridge, Addenbrookes Hospital, Cambridge, UK. (FIA, OG)
ID# 1561
Tags: Animals, Biological Tumor Markers/metabolism, Carrier Proteins/metabolism, Cell Surface Receptors/metabolism, Female, Fluorodeoxyglucose F18/pharmacology, Folate Receptor 1, GPI-Anchored Folate Receptors, Humans, Inbred BALB C Mice, Mice, Neoplasm Transplantation, Pharmaceutical Chemistry/methods, Positron-Emission Tomography (PET)/methods, Quinazolines/pharmacology, Thymidylate Synthase/antagonists & inhibitors, Time Factors