Diarra K. Williams et al. Genetic engineering a large animal model of human hypophosphatasia in sheep. Scientific Reports.
November 16 2018
How Analyze was Used
“For dental analyses, CT image stacks (DICOM) were exported as IMA files and reconstructed in AnalyzePro 1.0 (AnalyzeDirect, Overland Park, KS, USA). Sheep mandibles were oriented to a standard orientation using incisors as landmarks. Enamel was traced above a threshold of 1600 Hounsfield units (HU) and the threshold used for bone and dentin was 400 HU, with some manual correction done as necessary to separate bone and dentin. 3D facial and lingual views were prepared, with the latter rendering alveolar bone translucent to allow a view of incisor roots. 2D facial and sagittal (through right central incisor) views were prepared.”
Genetic engineering, Animal model, Hypophosphatasia, Sheep
Texas A&M University, College Station, Texas, USA