AnalyzeDirect Egerton A, Hirani E, Ahmad R, Turton DR, Brickute D, Rosso L, Howes OD, Luthra SK, Grasby PM. Further evaluation of the carbon11-labeled D2/3 agonist PET radiotracer PHNO: reproducibility in tracer characteristics and characterization of extrastriatal binding. Synapse. April 2010;64(4):301-312.
Full Text – Open Access
Publication Date
April 2010
How Analyze was Used
“Image volumes were then transferred into ANALYZE software for volume of interest (VOI) analysis (Robb, 2001).”
Keywords
Animals
Binding, Competitive
Carbon Radioisotopes/metabolism
Chromatography, High Pressure Liquid/methods
Corpus Striatum/drug effects/radionuclide imaging
Dopamine Agonists/metabolism
Male
Oxazines/metabolism/pharmacokinetics
Positron-Emission Tomography (PET)/methods
Protein Binding
Raclopride/metabolism/pharmacokinetics
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D2/agonists
Reproducibility of Results
Tissue Distribution
Author Affiliation(s)
Division of Neuroscience and Psychological Medicine, Department of Neuroscience and Mental Health, Imperial College London, London, UK. (AE, PMG)
Section of Neuroimaging, Institute of Psychiatry, King’s College London, UK. (AE, ODH)
Psychiatric Imaging Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London, UK. (AE, LR, ODH, PMG)
MDX Research, GE Healthcare, Hammersmith Hospital, London, UK. (EH, RA, SKL)
Hammersmith Imanet Ltd, GE Healthcare, Hammersmith Hospital, London, UK. (DRT, DB)
ID# 1157
Tags: Animals, Carbon Radioisotopes/metabolism, Competitive Binding, Corpus Striatum/drug effects/radionuclide imaging, Dopamine Agonists/metabolism, Dopamine D2 Receptors/agonists, High Pressure Liquid Chromatography/methods, Male, Oxazines/metabolism/pharmacokinetics, Positron-Emission Tomography (PET)/methods, Protein Binding, Raclopride/metabolism/pharmacokinetics, Rats, Reproducibility of Results, Sprague-Dawley Rats, Tissue Distribution