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Fenfluramine evokes 5-HT2A receptor-mediated responses but does not displace [11C]MDL 100907: small animal PET and gene expression studies

Hirani E, Sharp T, Sprakes M, Grasby P, Hume S. Fenfluramine evokes 5-HT2A receptor-mediated responses but does not displace [11C]MDL 100907: small animal PET and gene expression studies. Synapse. December 2003;50(3):251-260.

Publication Date
December 2003

How Analyze was Used
“Data were transferred into ANALYZE-AVW imaging software (Robb, 2001) and a standard VOI template, drawn from 0.5 mm- interval slices illustrated in Paxinos and Watson (1996) and described in Hume et al. (2001), was pro- jected onto each image volume.”

Keywords
Animals
Carbon Radioisotopes/diagnostic use
Cerebellum/drug effects/metabolism
Fenfluramine/metabolism/pharmacology
Fluorobenzenes/diagnostic use/pharmacology
Gene Expression/drug effects
Genes, Immediate-Early/drug effects
In Situ Hybridization
Ketanserin/pharmacology
Male
Neurons/drug effects/metabolism
Piperidines/diagnostic use/pharmacology
Rats
Rats, Sprague-Dawley
Receptor, Serotonin, 5-HT2A/metabolism
Serotonin/metabolism
Serotonin Antagonists/diagnostic use/pharmacology
Serotonin Uptake Inhibitors/metabolism/pharmacology
Time Factors
Tomography, Emission-Computed/methods

Author Affiliation(s)
Imaging Research Solutions Ltd., Cyclotron Building, London W12 0NN, UK. (EH, SH)

MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, UK. (PG)

Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. (TS, MS)

ID# 2474

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