AnalyzeDirect Schmerbach K, Pfab T, Zhao Y, Culman J, Mueller S, Villringer A, Muller DN, Hocher B, Unger T, Thoene-Reineke C. Effects of aliskiren on stroke in rats expressing human renin and angiotensinogen genes. PLoS One. November 2010;5(11):e15052.
Full Text – Open Access
Publication Date
November 2010
How Analyze was Used
“Calculation of lesion volume was carried out with Analyze 5.0 (AnalyzeDirect Inc., Lenexa, KS, USA).”
Keywords
Amides/pharmacology
Angiotensinogen/antagonists & inhibitors/genetics/physiology
Animals
Animals, Genetically Modified
Antihypertensive Agents/pharmacology
Benzimidazoles/pharmacology
Blood Pressure/drug effects
Brain/blood supply/drug effects/metabolism
Brain Ischemia/genetics/physiopathology
Cerebral Arterial Diseases/physiopathology
Cerebrovascular Disorders/physiopathology
Chemokine CXCL1/genetics
Fumarates/pharmacology
Gene Expression/drug effects
Humans
Interleukin-6/genetics
Rats
Renin/antagonists & inhibitors/genetics/physiology
Reverse Transcriptase Polymerase Chain Reaction
Stroke/drug therapy/genetics/physiopathology
Tetrazoles/pharmacology
Tumor Necrosis Factor-alpha/genetics
Author Affiliation(s)
Center for Cardiovascular Research/Institute of Pharmacology, Charité, Berlin, Germany. (KS, TP, BH, TU, CTR)
Department of Nephrology, Charité Campus Benjamin Franklin, Berlin, Germany. (TP)
Institute of Experimental and Clinical Pharmacology, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany. (YZ, JC)
Center for Stroke Research Berlin, Charité, Berlin, Germany. (SM)
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. (AV)
Max Delbrueck Center for Molecular Medicine, Berlin, Germany. (DNM)
Institute of Nutritional Science, University of Potsdam, Potsdam, Germany. (BH)
Department of Experimental Medicine (FEM), Charité, Berlin, Germany. (CTR)
ID# 1033
Tags: Amides/pharmacology, Angiotensinogen/antagonists & inhibitors/genetics/physiology, Animals, Antihypertensive Agents/pharmacology, Benzimidazoles/pharmacology, Blood Pressure/drug effects, Brain Ischemia/genetics/physiopathology, Brain/blood supply/drug effects/metabolism, Cerebral Arterial Diseases/physiopathology, Cerebrovascular Disorders/physiopathology, Chemokine CXCL1/genetics, Fumarates/pharmacology, Gene Expression/drug effects, Genetically Modified Animals, Humans, Interleukin-6/genetics, Rats, Renin/antagonists & inhibitors/genetics/physiology, Reverse Transcriptase Polymerase Chain Reaction, Stroke/drug therapy/genetics/physiopathology, Tetrazoles/pharmacology, Tumor Necrosis Factor-alpha/genetics