AnalyzeDirect Kempen DHR, Lu L, Heijink A, Hefferan TE, Creemers LB, Maran A, Yaszemski MJ, Dhert WJA. Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration. Biomaterials. May 2009;30(14):2816-2825.
Publication Date
May 2009
How Analyze was Used
“Reconstructions of the vessels and bone were made with standardized thresholds using the Analyze software package… The μCT scans of ectopic implants were used to quantify the volume of the vascular support network and newly formed bone.”
Keywords
Animals
Bone Morphogenetic Protein 2/chemistry/therapeutic use
Bone Regeneration/drug effects
Disease Models, Animal
Drug Delivery Systems/methods
Fractures, Bone/drug therapy/pathology/radiography
Neovascularization, Physiologic/drug effects
Rats
Vascular Endothelial Growth Factor A/chemistry/therapeutic use
X-Ray Microtomography
Author Affiliation(s)
Department of Orthopedics, University Medical Center, Heidelberglaan 100, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. (DHRK, LBC,AM, WJAD)
Tissue Engineering and Biomaterials Laboratory, Departments of Orthopedic Surgery and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, US. (DHRK, LL, AH, TEH, MJY)
ID# 1357
Tags: Animal Disease Models, Animals, Bone Fractures/drug therapy/pathology/radiography, Bone Morphogenetic Protein 2/chemistry/therapeutic use, Bone Regeneration/drug effects, Drug Delivery Systems/methods, Physiologic Neovascularization/drug effects, Rats, Vascular Endothelial Growth Factor A/chemistry/therapeutic use, X-Ray Microtomography