AnalyzeDirect

Miles KM, Seshadri M, Ciamporcero E, Adelaiye R, Gillard B, Sotomayor P, Attwood K, Shen L, Conroy D, Kuhnert F, Lalani AS, Thurston G, Pili R. Dll4 blockade potentiates the anti-tumor effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts. PLoS One. November 2014;9(11):e112371.

Full Text – Open Access

Publication Date
November 2014

How Analyze was Used
“Raw image sets were transferred to a processing workstation and converted into Analyze format (Analyze 7.0, AnalyzeDirect, Overland Park, KS, USA). Linear regression analysis of the normalized change in R1 versus time curve was carried out to compute the relative blood volume of tumors.”

Keywords
Agent-Based Modeling
Body Weight
Cancer Therapy
Cancer Treatment
Magnetic Resonance Imaging (MRI)
Renal Cell Carcinoma
Tumor Angiogenesis
VEGF Signaling

Author Affiliation(s)
Genitourinary Program, Roswell Park Cancer Institute, Buffalo, New York, US. (KMM, LS, DC, RP)

Department of Pharmacology & Therapeutics, Roswell Park Cancer Institute Division, University at Buffalo, Buffalo, New York, US. (MS, BG)

Department of Cancer Pathology & Prevention, Roswell Park Cancer Institute Division, University at Buffalo, Buffalo, New York, US. (RA, RP)

Department of Molecular and Cellular Biology, Roswell Park Cancer Institute Division, University at Buffalo, Buffalo, New York, US. (PS)

Department of Biostatistics & Bioinformatics, Roswell Park Cancer Institute Division, University at Buffalo, Buffalo, New York, US. (KA)

Medicine and Experimental Oncology, University of Turin, Turin, Italy. (EC)

Regeneron Pharmaceuticals, Inc., Tarrytown, New York, US. ( FK, ASL, GT)

ID# 916

Tags: Agent-Based Modeling, Body Weight, Cancer Therapy, Cancer Treatment, Magnetic Resonance Imaging (MRI), Renal Cell Carcinoma, Tumor Angiogenesis, VEGF Signaling