Kristen L. Nowak et al. Curcumin therapy to treat vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease: Design and baseline characteristics of participants Contemporary Clinical Trials Communications.
August 12, 2020
How Analyze was Used
“MRIs to quantify TKV were acquired using a 3-T Siemens Skyra magnet (Siemens Healthcare USA, Tarrytown, NY). Renal images were acquired in similar manner and volumetric measurements determined as described for the CRISP study, by stereology using Analyze software (Analyze 11.0). No contrast agents were utilized. Individuals involved in the acquisition and analysis of images were blinded regarding group assignment. For analysis, DICOM images were de-identified and evaluated by a single analyst using Analyze software (Analyze 11.0). To account for normal growth in children, TKV and was adjusted for height (htTKV). In addition, height-adjusted cyst volume, fractional cyst volume (percent of TKV measured as cystic), and renal parenchyma (TKV – cyst volume) were measured. Mayo classification was determined for those participants ≥15 years of age.”
ADPKD, Clinical trial, Flow-mediated dilation, Pediatric, Pulse-wave velocity, Total kidney volume
University of Colorado Anschutz Medical Campus, Aurora, CO, USA