AnalyzeDirect

Benjamin A. Lakin^1,2, Harsh Patel^1,2, Conor Holland², Jonathan D. Freedman^1,3, Joshua S. Shelofsky^1,2, Brian D. Snyder^1,4, Kathryn S. Stok^5,6, and Mark W. Grinstaff^2,7. Contrast-enhanced CT using a cationic contrast agent enables non-destructive assessment of the biochemical and biomechanical properties of mouse tibial plateau cartilage. Journal of Orthopaedic Research. December 21, 2015.

Publication Date
December 2015

How Analyze was Used
“For each time point, the cartilage was segmented from the subchondral bone using a region-growing algorithm in the Volume Edit module of Analyze”

Keywords
micro-computed tomography
compressive modulus
coefficient of friction
osteoarthritis
glycosaminoglycan

Author Affiliation(s)
¹ Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
² Department of Biomedical Engineering, Boston University, Boston, MA
³ Department of Pharmacology and Experimental Therapeutics, Boston University, Boston, MA
⁴ Department of Orthopaedic Surgery, Children’s Hospital, Boston, MA
⁵ Institute for Biomechanics, ETH Zürich, Zürich, Switzerland
⁶ Scanco Medical AG, Brüttisellen, Switzerland
⁷ Department of Chemistry, Boston University, Boston, MA

Tags: Cartilage, Micro-Computed Tomography, Osteoarthritis