AnalyzeDirect Barrett KM, Ding YH, Wagner DP, Kallmes DF, Johnston KC. Change in diffusion-weighted imaging infarct volume predicts neurologic outcome at 90 days: results of the Acute Stroke Accurate Prediction (ASAP) trial serial imaging substudy. Stroke. July 2009;40(7):2422-2427.
Full Text – Open Access
Publication Date
July 2009
How Analyze was Used
“DWI infarct volumes were measured by one of 2 readers blinded to clinical outcome using computer-assisted volumetric software (Analyze software 6.1 …). A pen-trace method was used to outline the region of interest (ie, area of acute stroke) on each axial image and the total volume was reported in cubic centimeters. In cases of multifocal infarction, the sum of the individual volumes was used. Change in DWI infarct volume was calculated by subtracting the baseline DWI infarct volume from the follow-up DWI infarct volume according to the following formula:
Δ infarct volume (cm3)=follow-up volume (cm3)−baseline volume (cm3).
Change in infarct volume as calculated by this formula was termed “growth” and categorized into one of 4 mutually exclusive clinically relevant categories chosen before analysis of the data: (1) < 0 to 10 cm3 (e.g., follow-up infarct volume smaller than baseline); (2) >0 to 10 cm3; (3) >10 to 20 cm3; and (4) >20 cm3.”
Keywords
Aged
Cerebral Infarction/diagnosis/pathology
Diffusion Magnetic Resonance Imaging
Female
Follow-Up Studies
Humans
Male
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Prognosis
Prospective Studies
Sensitivity and Specificity
Severity of Illness Index
Stroke/diagnosis/pathology
Author Affiliation(s)
Department of Neurology, Mayo Clinic Florida, Jacksonville, FL. (KMB)
Departments of Neurology, University of Virginia, Charlottesville, VA. (KCJ)
Public Health Sciences, University of Virginia, Charlottesville, VA. (KCJ, DPW)
Department of Radiology, Mayo Clinic Rochester, Rochester, MN. (YHD, DFK)
ID# 1288
Tags: Aged, Cerebral Infarction/diagnosis/pathology, Diffusion Magnetic Resonance Imaging, Female, Follow-Up Studies, Humans, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Prognosis, Prospective Studies, Sensitivity and Specificity, Severity of Illness Index, Stroke/diagnosis/pathology