AnalyzeDirect

Jun Ku Chung^1,2, Shinichiro Nakajima^2,3,4,5, Shunichiro Shinagawa⁶, Eric Plitman^1,2, M. Mallar Chakravarty^7,8, Yusuke Iwata^2,4, Fernando Caravaggio^1,2, Bruce G. Pollock^1,3,5, Philip Gerretsen^2,3,5, Ariel Graff-Guerrero^1,2,3,5. Benzodiazepine Use Attenuates Cortical Beta-Amyloid and is Not Associated with Progressive Cognitive Decline in Non-Demented Elderly Adults: A Pilot Study Using F18 -Florbetapir Positron Emission Tomography. The American Journal of Geriatric Psychiatry. 04 May 2016.

Publication Date
May 2016

How Analyze was Used
“A voxel-based confirmatory analysis was carried out in PRE+BZD and PRE-BZD users using Analyze 6.0 (AnalyzeDirect, Overland Park, KS) software.”

Keywords
Benzodiazepine
beta-amyloid
cognition
function
GABA-A
Alzheimer’s disease

Author Affiliation(s)
¹Institute of Medical Science, Faculty of Medicine, University of Toronto
²Multimodal Imaging Group – Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada
³Department of Psychiatry, University of Toronto, Toronto, Canada
⁴Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan
⁵Geriatric Mental Health Division, Centre for Addiction and Mental Health, Toronto, Canada
⁶Department of Psychiatry, The Jikei University School of Medicine
⁷Cerebral Imaging Centre, Douglas Mental Health Institute, McGill University, Montreal, Quebec, Canada
⁸Department of Psychiatry and Biomedical Engineering, McGill University, Montreal, Quebec, Canada

Tags: Alzheimer's Disease, Benzodiazepines, Beta Amyloid (Aβ), Cognition, Gaba