AnalyzeDirect Wiessner C, Bareyre FM, Allegrini PR, Mir AK, Frentzel S, Zurini M, Schnell L, Oertle T, Schwab ME. Anti-Nogo-A antibody infusion 24 hours after experimental stroke improved behavioral outcome and corticospinal plasticity in normotensive and spontaneously hypertensive rats. J Cereb Blood Flow Metab. February 2003;23(2):154-165.
Full Text – Open Access
Publication Date
February 2003
How Analyze was Used
“For morphometric evaluation, damaged tissue was segmented by setting an intensity threshold using a semiautomatic image analysis software (Analyze).”
Keywords
Animals
Antibodies, Monoclonal/administration & dosage/pharmacokinetics
Arterial Occlusive Diseases/complications
Behavior, Animal/drug effects
Brain/metabolism
Cerebral Arteries
Cerebral Infarction/etiology/pathology/psychology
Drug Administration Schedule
Hypertension/complications
Injections, Intraventricular
Male
Myelin Proteins/immunology
Neuronal Plasticity/drug effects
Pyramidal Tracts/pathology/physiopathology
Rats
Rats, Inbred F344
Rats, Inbred SHR
Stroke/etiology/physiopathology/psychology
Tissue Distribution
Author Affiliation(s)
Nervous System Research, Novartis Pharma AG, Basel, Switzerland. (CW, AKM, SF)
Core Technology Area, Novartis Pharma AG, Basel, Switzerland. (PRA, MZ)
Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland. (FMB, LS, TO, MES)
ID# 2390
Tags: Animal Behavior/drug effects, Animals, Arterial Occlusive Diseases/complications, Brain/metabolism, Cerebral Arteries, Cerebral Infarction/etiology/pathology/psychology, Drug Administration Schedule, Hypertension/complications, Inbred F344 Rats, Inbred SHR Rats, Intraventricular Injections, Male, Monoclonal Antibodies/administration & dosage/pharmacokinetics, Myelin Proteins/immunology, Neuronal Plasticity/drug effects, Pyramidal Tracts/pathology/physiopathology, Rats, Stroke/etiology/physiopathology/psychology, Tissue Distribution