AnalyzeDirect Melanie Vogler et al. An antagonistic monoclonal anti–Plexin-B1 antibody exerts therapeutic effects in mouse models of postmenopausal osteoporosis and multiple sclerosis JOR Spine.
Publication Date
July 15, 2022
How Analyze was Used
“Reconstructed volumes were loaded into Analyze14 software (AnalyzeDirect) for 3D segmentation of the bone structure by thresholds method. Group sizes had been designed to be equal, that is, n = 15 for both control IgG- and RbPLX7-treated mice. However, after data analysis, regenotyping of mice revealed that in the control IgG-treated group, two mice had an incorrect genotype (i.e., they were Plexin-B1–deficient mice instead of humanized Plexin-B1 mice). For this reason, these two mice had to be excluded from statistical analysis, reducing group size for IgG-treated mice to n = 13.”
Keywords
Antibody, Monoclonal antibody, Multiple sclerosis, Experimental autoimmune encephalomyelitis, Osteoporosis, Plexin, Semaphorin, Plexin-B1, Sema4D, CD100
Author Affiliation(s)
Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
