AnalyzeDirect Chaparro J, Reeds DN, Wen W, Xueping E, Klein S, Semenkovich CF, Bae KT, Quirk EK, Powderly WG, Yarasheski KE, Li E. Alterations in thigh subcutaneous adipose tissue gene expression in protease inhibitor-based highly active antiretroviral therapy. Metabolism. May 2005;54(5):561-567.
Full Text – Open Access
Publication Date
May 2005
How Analyze was Used
“AnalyzeDirect software … was used to identify pixel intensities that corresponded to adipose tissue, identify and segment the regions of interest (eg, abdominal VAT, abdominal SAT, and thigh fat), and quantify the adipose tissue areas in each cross-sectional image.”
Keywords
Abdomen
Acquired Immunodeficiency Syndrome/drug therapy
Adipocytes/metabolism
Adipose Tissue/metabolism
Adult
Antiretroviral Therapy, Highly Active
Case-Control Studies
Cross-Sectional Studies
Cytokines/genetics
Female
Gene Expression/drug effects
HIV Seronegativity
Hiv-1
Humans
Male
Protease Inhibitors/therapeutic use
RNA, Messenger/metabolism
Regression Analysis
Reverse Transcriptase Polymerase Chain Reaction
Subcutaneous Tissue/metabolism
Thigh
Transcription Factors/genetics
Author Affiliation(s)
Departments of Medicine and Radiology, Washington University School of Medicine, St. Louis, MO 63110, US.
ID# 2110
Tags: Abdomen, Acquired Immunodeficiency Syndrome/drug therapy, Adipocytes/metabolism, Adipose Tissue/metabolism, Adult, Case-Control Studies, Cross Sectional Studies, Cytokines/genetics, Female, Gene Expression/drug effects, Highly Active Antiretroviral Therapy, HIV Seronegativity, Hiv-1, Humans, Male, Messenger RNA/metabolism, Protease Inhibitors/therapeutic use, Regression Analysis, Reverse Transcriptase Polymerase Chain Reaction, Subcutaneous Tissue/metabolism, Thigh, Transcription Factors/genetics