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Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: evidence for improving cardiac metabolic efficiency

Bao W, Aravindhan K, Alsaid H, Chendrimada T, Szapacs M, Citerone DR, Harpel MR, Willette RN, Lepore JJ, Jucker BM. Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: evidence for improving cardiac metabolic efficiency. PLoS One. August 2011;6(8):e23570.

Full Text – Open Access

Publication Date
August 2011

How Analyze was Used
“Left ventricle (LV) functional parameters were analyzed (Analyze AVW software, AnalyzeDirect, Lenexa, KS) [Schwartz 2000].”

Keywords
Animals
Blood Glucose/metabolism
Body Weight/drug effects
Cardiotonic Agents/pharmacology
Cyclic AMP/metabolism
Energy Metabolism/drug effects
Feeding Behavior/drug effects
Glucagon-Like Peptide 1/administration & dosage/analogs &
derivatives/blood/pharmacology
Heart
Heart Function Tests
Hemodynamics/drug effects
Insulin/blood
Lactic Acid/blood
Male
Metabolic Networks and Pathways/drug effects/genetics
Myocardial Infarction/complications/pathology/physiopathology
Myocardial Reperfusion Injury/complications/physiopathology/prevention & control
Myocardium/metabolism
Principal Component Analysis
Rats
Rats, Sprague-Dawley
Transcription, Genetic/drug effects

Author Affiliation(s)
Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapy Area Unit, GlaxoSmithKline, King of Prussia, PA, US. (WB, KA, MRH, RNW, JJL, BMJ)

Clinical Imaging Center, GlaxoSmithKline, King of Prussia, PA, US. (HA, TC)

Platform Technology and Science, GlaxoSmithKline, King of Prussia, PA, US. (MS, DRC)

ID# 754

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