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Kurenova E, Ucar D, Liao J, Yemma M, Gogate P, Bshara W, Sunar U, Seshadri M, Hochwald SN, Cance WG. A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells. Cell Cycle. October 2014;13(16):2542-2553.

Publication Date
October 2014

How Analyze was Used
“Raw image datasets were transferred to a workstation for post processing using AnalyzeTM (AnalyzeDirect, Overland Park, KS) and MATLAB (Version 7.0).”

Keywords
Cell Survival
Drug Resistance
Endothelial Cells
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases
Heterografts
Melanoma
Phosphorylation
Signal Transduction
Treatment Outcome
Vascular Endothelial Growth Factor Receptor-3

Author Affiliation(s)
Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, US. (EK, JL, MY, GP, SNH, WGC)

CureFAKtor Pharmaceuticals, Orchard Park, NY, US. (WB)

University of Florida, Gainesville, FL, US. (US)

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, US. (MS)

Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY US. (DU)

Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, US. (EK, WGC)

ID# 2698

Tags: Cell Survival, Drug Resistance, Endothelial Cells, Focal Adhesion Kinase 1, Focal Adhesion Protein-Tyrosine Kinases, Heterografts, Melanoma, Phosphorylation, Signal Transduction, Treatment Outcome, Vascular Endothelial Growth Factor Receptor-3