AnalyzeDirect Wagner CC, Simpson M, Zeitlinger M, Bauer M, Karch R, Abrahim A, Feurstein T, Schütz M, Kletter K, Müller M, Lappin G, Langer O. A combined accelerator mass spectrometry-positron emission tomography human microdose study with 14C- and 11C-labelled verapamil. Clin Pharmacokinet. February 2011;50(2):111-120.
Full Text – Open Access
Publication Date
February 2011
How Analyze was Used
“MRI and PET data were processed with PMOD 2.6 …, Analyze 8.0.”
Keywords
Area Under Curve
Blood-Brain Barrier
Calcium Channel Blockers/administration & dosage/blood/pharmacokinetics
Carbon Radioisotopes
Cross-Over Studies
Half-Life
Humans
Male
Models, Biological
Positron-Emission Tomography (PET)
Tandem Mass Spectrometry
Verapamil/administration & dosage/blood/pharmacokinetics
Author Affiliation(s)
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. (CCW, MZ, MB, AA, TF, MM, OL)
Xceleron Ltd, York, UK. (MS, GL)
Department of Medical Computer Sciences, Medical University of Vienna, Vienna, Austria. (RK)
Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria. (MS, KK)
Health & Environment Department, Molecular Medicine, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria. (OL)
ID# 716
Tags: Area Under Curve, Biological Models, Blood-Brain Barrier, Calcium Channel Blockers/administration & dosage/blood/pharmacokinetics, Carbon Radioisotopes, Cross-Over Studies, Half-Life, Humans, Male, Positron Emission Tomography (PET), Tandem Mass Spectrometry, Verapamil/administration & dosage/blood/pharmacokinetics