AnalyzeDirect Herrmann J, Best PJ, Ritman EL, Holmes DR, Lerman LO, Lerman A. Chronic endothelin receptor antagonism prevents coronary vasa vasorum neovascularization in experimental hypercholesterolemia. J Am Coll Cardiol. May 2002;39(9):1555-1561.
Full Text – Open Access
Publication Date
May 2002
How Analyze was Used
“The imaging system yielded a matrix of 42 μm cubic voxels with a 16 bits gray scale and an average number of 500 slices per coronary artery segment for analysis … The resulting three-dimensional digitalized image was analyzed by using the Analyze software package.”
Keywords
Animals
Blotting, Western
Cholesterol, Dietary/administration & dosage
Coronary Artery Disease/metabolism
Coronary Vessels/pathology
Disease Models, Animal
Endothelial Growth Factors/analysis
Endothelin Receptor Antagonists
Endothelin-1/metabolism
Female
Hypercholesterolemia/metabolism
Immunohistochemistry
Lymphokines/analysis
Neovascularization, Pathologic/metabolism/prevention & control
Swine
Tomography, X-Ray Computed (CT)/methods
Vasa Vasorum/pathology/radiography
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Author Affiliation(s)
Division of Cardiovascular Diseases, Mayo Clinic Rochester, Rochester, MN, US. (JH, PJB, DRH, AL)
Department of Physiology and Biophysics, Mayo Clinic Rochester, Rochester, MN, US. (ELR)
Department of Hypertension, Division of Internal Medicine, Mayo Clinic Rochester, Rochester, MN, US. (LOL)
ID# 2527
Tags: Animal Disease Models, Animals, Coronary Artery Disease/metabolism, Coronary Vessels/pathology, Dietary Cholesterol/administration & dosage, Endothelial Growth Factors/analysis, Endothelin Receptor Antagonists, Endothelin-1/metabolism, Female, Hypercholesterolemia/metabolism, Immunohistochemistry, Lymphokines/analysis, Pathologic Neovascularization/metabolism/prevention & control, Swine, Vasa Vasorum/pathology/radiography, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors, Western Blotting, X-Ray Computed Tomography (CT)/methods