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Dopamine D2 receptor occupancy levels of acute sulpiride challenges that produce working memory and learning impairments in healthy volunteers

Mehta MA, Montgomery AJ, Kitamura Y, Grasby PM. Dopamine D2 receptor occupancy levels of acute sulpiride challenges that produce working memory and learning impairments in healthy volunteers. Psychopharmacology (Berl). January 2008;196(1):157-165.

Publication Date
January 2008

How Analyze was Used
“An ROI for the region of the substantia nigra was based on a template developed in house. Time-activity curves for individual regions were then generated using Analyze 6.0 software (www.analyzedirect. com).”

Keywords
Adult
Affect/drug effects
Antipsychotic Agents/pharmacology
Carbon Radioisotopes/diagnostic use
Corpus Striatum/drug effects/radionuclide imaging
Dopamine Antagonists/diagnostic use
Dose-Response Relationship, Drug
Double-Blind Method
Humans
Male
Memory, Short-Term/drug effects
Motor Activity/drug effects
Neuropsychological Tests
Orientation/drug effects
Pain Measurement
Pattern Recognition, Visual/drug effects
Positron-Emission Tomography (PET)
Probability Learning
Prolactin/blood
Raclopride/diagnostic use
Reaction Time/drug effects
Receptors, Dopamine D2/drug effects
Serial Learning/drug effects
Sulpiride/pharmacology

Author Affiliation(s)
PET Psychiatry Group, MRC Clinical Sciences Centre, Hammersmith Hospital Imperial College, London, W12 0NN, UK. (MAM, AJM, YK, PMG)

Centre for Neuroimaging Sciences, Institute of Psychiatry, King’s College, London, SE5 8AF, UK. (MAM)

ID# 1516

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