AnalyzeDirect Jones KL, Finn DP, Governo RJM, Prior MJ, Morris PG, Kendall DA, Marsden CA, Chapman V. Identification of discrete sites of action of chronic treatment with desipramine in a model of neuropathic pain. Neuropharmacology. February 2009;56(2):405-413.
Publication Date
February 2009
How Analyze was Used
“All non-nervous tissue was then removed by manually masking around the brain of each middle
volume (Analyze software, version 1.0 …), saving as a binary template, and later applying to all remaining scan volumes.”
Keywords
Animals
Brain/blood supply/drug effects/pathology
Brain Mapping
Desipramine/therapeutic use
Disease Models, Animal
Drug Administration Schedule
Enzyme Inhibitors/therapeutic use
Hyperalgesia/drug therapy/etiology
Image Processing, Computer-Assisted/methods
Magnetic Resonance Imaging (MRI)
Male
Neuralgia/drug therapy/pathology
Oxygen/blood
Pain Threshold/drug effects
Physical Stimulation/adverse effects
Rats
Rats, Sprague-Dawley
Spinal Nerves/physiopathology
Author Affiliation(s)
Institute of Neuroscience, School of Biomedical Sciences, University of Nottingham, Nottingham NG7 2UH, UK. (KLJ, DPF, DK, CAM, VC)
Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham NG7 2UH, UK. (RJMG, MJP, PGM)
ID# 1350
Tags: Animal Disease Models, Animals, Brain Mapping, Brain/blood supply/drug effects/pathology, Computer-Assisted Image Processing/methods, Desipramine/therapeutic use, Drug Administration Schedule, Enzyme Inhibitors/therapeutic use, Hyperalgesia/drug therapy/etiology, Magnetic Resonance Imaging (MRI), Male, Neuralgia/drug therapy/pathology, Oxygen/blood, Pain Threshold/drug effects, Physical Stimulation/adverse effects, Rats, Spinal Nerves/physiopathology, Sprague-Dawley Rats