AnalyzeDirect Kapur S, Zipursky RB, Remington G, Jones C, DaSilva J, Wilson AA, Houle S. 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation. Am J Psychiatry. July 1998;155(7):921-928.
Full Text – Open Access
Publication Date
July 1998
How Analyze was Used
“The pertinent aspects are the following: striatal and cerebellar regions of interest were drawn on two contiguous PET slices on a composite PET image with reference to an MRI scan … coregistered to the PET scan by using a surface matching algorithm as implemented in ANALYZE 7.0.”
Keywords
Adult
Antipsychotic Agents/pharmacokinetics/therapeutic use
Benzodiazepines
Carbon Radioisotopes/diagnostic use
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Fluorine Radioisotopes/diagnostic use
Humans
Male
Pirenzepine/analogs & derivatives/pharmacokinetics/therapeutic use
Prolactin/blood
Pyrimidinones/diagnostic use
Raclopride
Receptors, Dopamine D2/drug effects/metabolism
Receptors, Serotonin/drug effects/metabolism
Salicylamides/diagnostic use
Schizophrenia/drug therapy/metabolism/radionuclide imaging
Tomography, Emission-Computed
Treatment Outcome
Author Affiliation(s)
Schizophrenia Division, Clarke Institute of Psychiatry, Toronto, Ontario, Canada.
ID# 2944
Tags: Adult, Antipsychotic Agents/pharmacokinetics/therapeutic use, Benzodiazepines, Carbon Radioisotopes/diagnostic use, Dopamine D2 Receptors/drug effects/metabolism, Drug Administration Schedule, Drug Dose-Response Relationship, Emission-Computed Tomography, Female, Fluorine Radioisotopes/diagnostic use, Humans, Male, Pirenzepine/analogs & derivatives/pharmacokinetics/therapeutic use, Prolactin/blood, Pyrimidinones/diagnostic use, Raclopride, Salicylamides/diagnostic use, Schizophrenia/drug therapy/metabolism/radionuclide imaging, Serotonin Receptors/drug effects/metabolism, Treatment Outcome