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3′-deoxy-3′-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography

Barthel H, Cleij MC, Collingridge DR, Hutchinson OC, Osman S, He Q, Luthra SK, Brady F, Price PM, Aboagye EO. 3′-deoxy-3′-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography. Cancer Res. July 2003;63(13):3791-3798.

Full Text – Open Access

Publication Date
July 2003

How Analyze was Used
“The image data sets obtained were transferred to a SUN workstation (Ultra 10; SUN Microsystems, Santa Clara, CA) and visualized using the Analyze software (version 4.0 …). ROIs were defined on three to six coronal planes for all tumors.”

Keywords
Adenosine Triphosphate/metabolism
Animals
Dideoxynucleosides/pharmacokinetics
Drug Monitoring/methods
Fluorine Radioisotopes/pharmacokinetics
Fluorodeoxyglucose F18/pharmacokinetics
Fluorouracil/therapeutic use
Humans
Mice
Mice, Inbred C3H
Mice, Nude
Neoplasms/drug therapy/radionuclide imaging
Neoplasms, Experimental/radionuclide imaging
Radiopharmaceuticals/pharmacokinetics
Tissue Distribution
Tomography, Emission-Computed
Transplantation, Heterologous

Author Affiliation(s)
Cancer Research United Kingdom PET Oncology Group, Department of Cancer Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital Campus, London W12 0NN, UK. (HB, MCC, DRC, OCH, PMP, EOA)

Imaging Research Solutions Limited, Cyclotron Building, Hammersmith Hospital, London W12 0NN, UK. (SO, SKL, FB)

Department of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany (HB)

Department of Oncology, Clinical Research Laboratory, Huddinge University Hospital, Karolinska Institute, S-171 76 Stockholm, Sweden. (QH)

ID# 2439

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