AnalyzeDirect Won-Bum Lee et al. Whitlockite nanoparticle-coated hydroxyapatite granules for bone regeneration in defect of rat calvaria Research Gate.
Publication Date
July 19, 2023
How Analyze was Used
“3D skull images of respective rat groups were obtained using a micro-CT system (Quantum FX micro CT, PerkinElmer, Waltham, USA) to evaluate the regeneration of newly formed bone in the defect site at the moment of 4 and 8 weeks after surgery. The CT scans were obtained at 90 kVp, 108 µA with a field-ofview (FOV) of 20 mm and voxel size of 39 µm. After scanning, a 3D image analysis was conducted using software (Analyze 12.0, AnalyzeDirect Inc., Overland Park, USA) where the region of interest (ROI) was defined as a cylindrical area covering calvarial defect (7.03mm (d.) × 2.92mm (h.)). Finally, bone volume/tissue volume (BV/TV, %) and bone mineral density (BMD, mg/cm3) were calculated within the
selected ROI.”
Keywords
Calvarial bone defect, Whitlockite, WHHAGs, BMP and Wnt signaling pathways, Bone
regeneration
Author Affiliation(s)
National Center for Nanoscience and Technology, Beijing, China
