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Köhler S, Thomas AJ, Lloyd A, Barber R, Almeida OP, O’Brien JT. White matter hyperintensities, cortisol levels, brain atrophy and continuing cognitive deficits in late-life depression. Br J Psychiatry. February 2010;196(2):143-149.

Full Text – Open Access

Publication Date
February 2010

How Analyze was Used
“For volumetric analyses, T1 images were then transferred to a Sun Ultra 10 work station running Solaris 2.7 … Hippocampal volume was analysed by a single operator (A.L.) who was masked to diagnosis using the AnalyzeAVW-3.0 software (AnalyzeDirect. com, Lenexa, Kansas, USA).”

Keywords
Aged
Aged, 80 and over
Atrophy/pathology
Brain/pathology
Cognition Disorders/blood/etiology/pathology
Depressive Disorder/blood/pathology/psychology
Diagnostic and Statistical Manual of Mental Disorders
Female
Follow-Up Studies
Humans
Hydrocortisone/metabolism
Magnetic Resonance Imaging (MRI)/methods
Male
Middle Aged
Neuropsychological Tests
Prognosis
Saliva/metabolism

Author Affiliation(s)
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK. (SK, AJT, RB, JTO)

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, SEARCH, EURON, Maastricht University, The Netherlands. (SK)

Institute of Neuroscience, Newcastle University, and Department of Psychiatry, The Royal Victoria Infirmary, Newcastle upon Tyne, UK. (AL)

School of Psychiatry and Clinical Neurosciences and Western Australian Centre for Health and Ageing, University of Western Australia, and Department of Psychiatry, Royal Perth Hospital, Perth, Australia. (OPA)

ID# 1027

Tags: Aged, Aged_80 and over, Atrophy/pathology, Brain/pathology, Cognition Disorders/blood/etiology/pathology, Depressive Disorder/blood/pathology/psychology, Diagnostic and Statistical Manual of Mental Disorders, Female, Follow-Up Studies, Humans, Hydrocortisone/metabolism, Magnetic Resonance Imaging (MRI)/methods, Male, Middle Aged, Neuropsychological Tests, Prognosis, Saliva/metabolism