AnalyzeDirect Melichar JK, Hume SP, Williams TM, Daglish MR, Taylor LG, Ahmad R, Malizia AL, Brooks DJ, Myles JS, Lingford-Hughes A, Nutt DJ. Using [11C]diprenorphine to image opioid receptor occupancy by methadone in opioid addiction: clinical and preclinical studies. J Pharmacol Exp Ther. January 2005;312(1):309-315.
Full Text – Open Access
Publication Date
January 2005
How Analyze was Used
“Each reconstructed frame of [11C]diprenorphine uptake acquired was analyzed on a Sun SPARC workstation … using AnalyzeAVW version 3.1.”
Keywords
Adult
Animals
Behavior, Addictive
Carbon Radioisotopes
Diprenorphine/chemistry/pharmacology
Humans
Male
Methadone/pharmacology
Middle Aged
Opioid-Related Disorders/metabolism
Rats
Rats, Sprague-Dawley
Receptors, Opioid/metabolism
Time Factors
Author Affiliation(s)
Psychopharmacology Unit, University of Bristol, Bristol, UK. (JKM, TMW, MRCD, LGT, ALM, ALH, DJN)
Hammersmith Imanet Ltd., Hammersmith Hospital, London, UK. (SPH, RA)
Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK. (DJB)
Bristol Specialist Drug Service, Blackberry Hill Hospital, Bristol, UK. (JSM)
ID# 2166
Tags: Addictive Behavior, Adult, Animals, Carbon Radioisotopes, Diprenorphine/chemistry/pharmacology, Humans, Male, Methadone/pharmacology, Middle Aged, Opioid Receptors/metabolism, Opioid-Related Disorders/metabolism, Rats, Sprague-Dawley Rats, Time Factors