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Caspase-2 in Lung Tumorigenesis and Chemotherapy

Cancers are generally caused by protein loss or gain of function, mutations of multiple genes or impairment in the regulation of cell signaling pathways. Dysregulation of caspases, proteins that act as effectors of cell death by cleaving cellular substrates, characterize diseases including inflammatory disorders and cancers. Caspase-2 is one of the most evolutionarily conserved caspases,…