AnalyzeDirect C.Y.J. Wenham1,2, S. Balamoody2, A.J. Grainger2, E.M.A. Hensor1,2, S. Draycott3, R. Hodgson2, P.G. Conaghan1,2. The responsiveness of novel, dynamic, contrast-enhanced magnetic resonance measures of total knee synovitis after intra-articular corticosteroid for painful osteoarthritis. Osteoarthritis and Cartilage, Volume 22 , Issue 10 , 1614 – 1618.
Full Text – Open Access
Publication Date
May 2014
How Analyze was Used
“Total synovial volume was calculated using the Analyze soft-ware (version 10.0). Difference images were created from the first pre-gadolinium series and the final post-gadolinium series. Semi-automatic segmentation of the enhancing synovium was performed from the difference images of the entire knee joint using a combination of thresholding functions and manual correction. The 3D segmentation was overlaid on the 4D dynamic series and values for total synovial volume and mean synovial signal intensity (SI) for each dynamic series generated.”
Keywords
Osteoarthritis
Synovium
Intra-articular Corticosteroid
Dynamic Magnetic Resonance Imaging
Biomarker
Knee
Author Affiliation(s)
1 Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, UK
2 NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK
3 Leeds Teaching Hospitals NHS Trust, Leeds, UK