Hui Liu et al. The impact of dopamine D2-like agonist/antagonist on [18F]VAT PET measurement of VAChT in the brain of nonhuman primates. European Journal of Pharmaceutical Sciences.
November 15, 2019
How Analyze was Used
“The magnetization-prepared rapid gradient echo (MP-RAGE) MR image and subsequent PET images were co-registered to the target PET image using an automated image registration program Automated Image Registration (AIR), and superimposed using Analyze 10.0 (AnalyzeDirect, Overland Park, KS). Regions of interest (ROIs), including striatum and cerebellar hemispheres, were manually drawn on MP-RAGE images for brain, and yield the volumes of interest (VOIs). The VOIs were transformed to the baseline PET space and then overlaid on all reconstructed PET images. Time-activity curves (TACs) were generated from the dynamic PET images. Activity concentration measures were calculated and standardized to the body weight and the injected dose of radioactivity, and yielded standardized uptake value (SUV). SUV ratio (SUVR) of striatum to cerebellar hemispheres was then obtained.”
Vesicular acetylcholine transporter, [18F], VATPET, Dopaminergic, D2-like drugs, Nonhuman primates
Washington University School of Medicine, St. Louis, Missouri, USA