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The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea

Placidi E, Marciani L, Hoad CL, Napolitano A, Garsed KC, Pritchard SE, Cox EF, Costigan C, Spiller RC, Gowland PA. The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea. Aliment Pharmacol Ther. July 2012;36(1):64-73.

Full Text – Open Access

Publication Date
July 2012

How Analyze was Used
“Measurements of the gastric emptying were performed by manually drawing the region of interest on each slice using Analyze 9 software, and summing across all the slices to determine the total volume at each time point.”

Keywords
Adult
Antidiarrheals/therapeutic use
Antifoaming Agents/therapeutic use
Body Water/metabolism
Cross-Over Studies
Diarrhea/chemically induced/drug therapy/metabolism
Double-Blind Method
Drug Therapy, Combination
Female
Gastrointestinal Motility/physiology
Humans
Intestinal Absorption/physiology
Intestine, Small/metabolism
Loperamide/therapeutic use
Magnetic Resonance Imaging (MRI)
Male
Mannitol/adverse effects
Middle Aged
Simethicone/therapeutic use
Young Adult

Author Affiliation(s)
Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, UK. (EP, CLH, SEP, EFC, CC, PAG)

Nottingham Digestive Diseases Centre and NIHR Biomedical Research Unit, Queen’s Medical Centre Campus, Nottingham University Hospitals, University of Nottingham, Nottingham, UK. (LM, KCG, RCS)

Division of Radiological and Imaging Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham, UK. (AN)

Department of Occupational Health and Safety, Medical Physics, Bambino Gesù Children’s Hospital, Rome, Italy. (AN)

ID# 608

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