AnalyzeDirect Riss PJ, Piel M, Bockhart V, Bausbacher N, Buchholz HG, Lueddens H, Roesch F. The DAT ligand [18F]PR17.MZ mirrors the in vivo pharmacokinetic profile of [11C]cocaine with significantly improved monoamine transporter selectivity. ChemMedChem. October 2010;5(10):1686-1688.
Publication Date
October 2010
How Analyze was Used
“Three-dimensional image data were generated. Analyze 8.1… and pmod (http://www.pmod.com) software were used for data evaluation.”
Keywords
Animals
Biogenic Monoamines/metabolism
Carbon Radioisotopes/chemistry
Cocaine/analogs & derivatives/chemical synthesis/chemistry/pharmacokinetics
Contrast Media/chemical synthesis/chemistry/pharmacokinetics
Dopamine Plasma Membrane Transport Proteins/antagonists & inhibitors/metabolism
Fluorine Radioisotopes/chemistry
Ligands
Positron-Emission Tomography (PET)
Radiopharmaceuticals/chemical synthesis/chemistry/pharmacokinetics
Rats
Rats, Sprague-Dawley
Author Affiliation(s)
The Wolfson Brain Imaging Centre, University of Cambridge, Box 65 Addenbrooke’s Hospital, CB2 0QQ, Cambridge, UK. (PJR)
Institute of Nuclear Chemistry, Johannes Gutenberg University, Fritz-Strassmann-Weg 2, 55128 Mainz, Germany. (PJR, MP, FR)
Molecular Biology Laboratory, Department of Psychiatry, Johannes Gutenberg University, 55128 Mainz, Germany. (VB, HL)
Department of Nuclear Medicine, Johannes Gutenberg University, 55131 Mainz, Germany. (NB, H-GB)
ID# 1112
Tags: Animals, Biogenic Monoamines/metabolism, Carbon Radioisotopes/chemistry, Cocaine/analogs & derivatives/chemical synthesis/chemistry/pharmacokinetics, Contrast Media/chemical synthesis/chemistry/pharmacokinetics, Dopamine Plasma Membrane Transport Proteins/antagonists & inhibitors/metabolism, Fluorine Radioisotopes/chemistry, Ligands, Positron Emission Tomography (PET), Radiopharmaceuticals/chemical synthesis/chemistry/pharmacokinetics, Rats, Sprague-Dawley Rats